There was the Spanish town, St.Augustine.

Thence Spanish ships might put forth and descend upon the English newcomers.
The colonists after debate concluded to set some further space between them and lands of Spain.

The ships put again to sea, beat northward a few leagues, and at last entered a harbor into which emptied two rivers, presently to be called the Ashley and the Cooper.

Up the Ashley they went a little way, anchored, and the colonists going ashore began to build upon the west bank of the river a town which for the King they named Charles Town.

Ten years later this place was abandoned in favor of the more convenient point of land between the two rivers.