As at first he did not know on whom his suspicions should fall, he gave the strictest orders for the pursuit of the murderers; but little by little the infamous truth was forced upon him.

He saw that the blow which struck at his house came from that very house itself and then his despair was changed to madness: he ran through the rooms of the Vatican like a maniac, and entering the consistory with torn garments and ashes on his head, he sobbingly avowed all the errors of his past life, owning that the disaster that struck his offspring through his offspring was a just chastisement from God; then he retired to a secret dark chamber of the palace, and there shut himself up, declaring his resolve to die of starvation.

And indeed for more than sixty hours he took no nourishment by day nor rest by night, making no answer to those who knocked at his door to bring him food except with the wailings of a woman or a roar as of a wounded lion; even the beautiful Giulia Farnese, his new mistress, could not move him at all, and was obliged to go and seek Lucrezia, that daughter doubly loved to conquer his deadly resolve.

Lucrezia came out from the retreat were she was weeping for the Duke of Gandia, that she might console her father.

At her voice the door did really open, and it was only then that the Duke of Segovia, who had been kneeling almost a whole day at the threshold, begging His Holiness to take heart, could enter with servants bearing wine and food.
The pope remained alone with Lucrezia for three days and nights; then he reappeared in public, outwardly calm, if not resigned; for Guicciardini assures us that his daughter had made him understand how dangerous it would be to himself to show too openly before the assassin, who was coming home, the immoderate love he felt for his victim..