On the 25th of January, 1494, he passed away, at the age of seventy, after a thirty-six years' reign, leaving the throne to his elder son, Alfonso, who was immediately chosen as his successor.
Ferdinand never belied his title of "the happy ruler." His death occurred at the very moment when the fortune of his family was changing.
The new king, Alfonso, was not a novice in arms: he had already fought successfully against Florence and Venice, and had driven the Turks out of Otranto; besides, he had the name of being as cunning as his father in the tortuous game of politics so much in vogue at the Italian courts.
He did not despair of counting among his allies the very enemy he was at war with when Charles VIII first put forward his pretensions, we mean Bajazet II.

So he despatched to Bajazet one of his confidential ministers, Camillo Pandone, to give the Turkish emperor to understand that the expedition to Italy was to the King of France nothing but a blind for approaching the scene of Mahomedan conquests, and that if Charles VIII were once at the Adriatic it would only take him a day or two to get across and attack Macedonia; from there he could easily go by land to Constantinople.

Consequently he suggested that Bajazet for the maintenance of their common interests should supply six thousand horse and six thousand infantry; he himself would furnish their pay so long as they were in Italy.

It was settled that Pandone should be joined at Tarentum by Giorgia Bucciarda, Alexander VI's envoy, who was commissioned by the pope to engage the Turks to help him against the Christians.

But while he was waiting for Bajazet's reply, which might involve a delay of several months, Alfonso requested that a meeting might take place between Piero dei Medici, the pope, and himself, to take counsel together about important affairs.