There was more than this to be considered: Louis XII's rest in Lombardy was only a halt, and Milan was evidently but the stage before Naples.

It was very possible that Louis was annoyed about the marriage which converted his enemy's nephew into the son-in-law of his ally.

Whereas, if Alfonso were dead, Lucrezia would be the position to marry some powerful lord of Ferrara or Brescia, who would be able to help his brother-in-law in the conquest of Romagna.

Alfonso was now not only useless but dangerous, which to anyone with the character of the Borgias perhaps seemed worse, the death of Alfonso was resolved upon.
But Lucrezia's husband, who had understand for a long time past what danger he incurred by living near his terrible father-in-law, had retired to Naples.

Since, however, neither Alexander nor Caesar had changed in their perpetual dissimulation towards him, he was beginning to lose his fear, when he received an invitation from the pope and his son to take part in a bull-fight which was to be held in the Spanish fashion in honour of the duke before his departure: In the present precarious position of Naples it would not have been good policy far Alfonso to afford Alexander any sort of pretext for a rupture, so he could not refuse without a motive, and betook himself to Rome.