At an early date the coast colonies began to trade with the Indian tribes of the back country: the Catawbas of the Yadkin Valley; the Cherokees, whose towns were scattered through Tennessee; the Chickasaws, to the westward in northern Mississippi; and the Choctaws farther to the southward.

Even before the beginning of the eighteenth century, when the South Carolina settlements extended scarcely twenty miles from the coast, English traders had established posts among the Indian tribes four hundred miles to the west of Charleston.

Following the sporadic trading of individuals from Virginia with the inland Indians, the heavily laden caravans of William Byrd were soon regularly passing along the Great Trading Path from Virginia to the towns of the Catawbas and other interior tribes of the Carolinas, delighting the easily captivated fancy and provoking the cupidity of the red men with "Guns, Powder, Shot, Hatchets (which the Indians call Tomahawks), Kettles, red and blue Planes, Duffields, Stroudwater blankets, and some Cutlary Wares, Brass Rings and other Trinkets." In Pennsylvania, George Croghan, the guileful diplomat, who was emissary from the Council to the Ohio Indians (1748), had induced "all-most all the Ingans in the Woods" to declare against the French; and was described by Christopher Gist as a "meer idol among his countrymen, the Irish traders." Against these advances of British trade and civilization, the French for four decades had artfully struggled, projecting tours of exploration into the vast medial valley of the continent and constructing a chain of forts and trading-posts designed to establish their claims to the country and to hold in check the threatened English thrust from the east.

Soon the wilderness ambassador of empire, Celoron de Bienville, was despatched by the far-visioned Galissoniere at Quebec to sow broadcast with ceremonial pomp in the heart of America the seeds of empire, grandiosely graven plates of lasting lead, in defiant yet futile symbol of the asserted sovereignty of France.

Thus threatened in the vindication of the rights of their colonial sea-to-sea charters, the English threw off the lethargy with which they had failed to protect their traders, and in grants to the Ohio and Loyal land companies began resolutely to form plans looking to the occupation of the interior.