He had his own mother committed to prison in 1487 under the gravest charges, whereupon he himself was confined in the castle of S.Angelo by Innocent VIII.

He escaped from prison, and the matter was allowed to drop.

He was a prothonotary of the Church.

His elder sister was married to Puccio Pucci, one of the most illustrious statesmen of Florence, a member of a large family which was on terms of close friendship with the Medici.
On the twentieth of May, 1489, the youthful Giulia Farnese, together with the equally youthful Orsino Orsini, appeared in the "Star Chamber" of the Borgia palace to sign their marriage contract.

It is worthy of note that this occurred in the house of Cardinal Rodrigo.