What position he held in Rome we do not know.
He married his daughter Adriana to Ludovico, a member of the noble house of Orsini, and lord of Bassanello, near Civita Castellana.

As the offspring of this union, Orsino Orsini, married in 1489, it is evident that his mother must have entered into wedlock at least sixteen years before.

Ludovico Orsini died in 1489 or earlier.

As his wife, and later as his widow, Adriana occupied one of the Orsini palaces in Rome, probably the one on Monte Giordano, near the Bridge of S.Angelo, this palace having subsequently been described as part of the estate which her son Orsino inherited.
Cardinal Rodrigo maintained the closest relations with Adriana.

She was more than his kinswoman; she was the confidant of his sins, of his intrigues and plans, and such she remained until the day of his death.
To her he entrusted the education of his daughter Lucretia during her childhood, as we learn from a letter written by the Ferrarese ambassador to Rome, Gianandrea Boccaccio, Bishop of Modena, to the Duke Ercole in 1493, in which he remarks of Madonna Adriana Ursina, "that she had educated Lucretia in her own house."[12] This doubtless was the Orsini palace on Monte Giordano, which was close to Cardinal Borgia's residence.
According to the Italian custom, which has survived to the present day, the education of the daughters was entrusted to women in convents, where the young girls were required to pass a few years, afterwards to come forth into the world to be married.