As a confidant and dependent of the Gonzaga he retained his connection with this princely house.[10] In his new position he assisted Ludovico Gonzaga, a brother of Francesco when he came to Rome in 1484 to receive the purple on his election as Bishop of Mantua.
Borgia was acquainted with Canale while he was in the service of the Gonzaga, and later he met him in the house of Sclafetano.

He selected him to be the husband of his widowed mistress, doubtless because Canale's talents and connections would be useful to him.
Canale, on the other hand, could have acquiesced in the suggestion to marry Vannozza only from avarice, and his willingness proves that he had not grown rich in his former places at the courts of cardinals.
The new marriage contract was drawn up June 8, 1486, by the notary of the Borgia house, Camillo Beneimbene, and was witnessed by Francesco Maffei, apostolic secretary and canon of S.Peter's; Lorenzo Barberini de Catellinis; a citizen, Giuliano Gallo, a considerable merchant of Rome; Burcardo Barberini de Carnariis, and other gentlemen.

As dowry Vannozza brought her husband, among other things, one thousand gold florins and an appointment as _sollicitator bullarum_.

The contract clearly referred to this as Vannozza's second marriage.

Would it not have been set down as the third, or in more general terms as new, if the alleged first marriage with Domenico d'Arignano had really been acknowledged?
In this instrument Vannozza's house on the Piazza de Branchis, in the Regola quarter, where the marriage took place, is described as her domicile.