Soon afterwards, in December the same year, death suddenly terminated the career of this young and brilliant upstart, then in Civitavecchia.

It is not known whether Don Pedro Luis Borgia was married or whether he left any descendants.[2] Cardinal Rodrigo Borgia lamented the loss of his beloved and, probably, only brother, and inherited his property, while his own high position in the Curia was not affected by the change in the papacy.

As vice-chancellor, he occupied a house in the Ponte quarter, which had formerly been the Mint, and which he converted into one of the most showy of the palaces of Rome.

The building encloses two courts, where may still be seen the original open colonnades of the lower story; it was constructed as a stronghold, like the Palazzo di Venizia, which was almost contemporaneous with it.

The Borgia palace, however, does not compare in architectural beauty or size with that built by Paul II.