There is a letter extant, written by Beatrice from Valencia to her brother shortly after he became pope.
Rodrigo Borgia was twenty-six when the dignity of cardinal was conferred upon him, and to this honor, a year later, was added the great office of vice-chancellor of the Church of Rome.

His brother, Don Pedro Luis, was only one year older; and Calixtus bestowed upon this young Valencian the highest honors which can fall to the lot of a prince's favorite.

Later we behold in him a papal nepot-prince in whom the Pope endeavored to embody all mundane power and honor; he made him his condottiere, his warder, his body-guard, and, finally, his worldly heir.

Calixtus allowed him to usurp every position of authority in the Church domain and, like a destroying angel, to overrun and devastate the republics and the tyrannies, for the purpose of founding a family dynasty, the Papacy being of only momentary tenure, and not transmittable to an heir.
Calixtus made Pedro Luis generalissimo of the Church, prefect of the city, Duke of Spoleto, and finally, vicar of Terracina and Benevento.
Thus in this first Spanish nepot was foreshadowed the career which Caesar Borgia later followed.
During the life of Calixtus the Spaniards were all-powerful in Rome.

In great numbers they poured into Italy from the kingdom of Valencia to make their fortune at the papal court as monsignori and clerks, as captains and castellans, and in any other way that suggested itself.
Calixtus III died on the sixth of August, 1458, and a few days later Don Pedro Luis was driven from Rome by the oppressed nobility of the country, the Colonna and the Orsini, who rose against the hated foreigner.