For the first time he found himself in Rome deprived of all his children.
Lucretia made the journey partly on horseback and partly in a litter, and the trip from Rome to Spoleto required not less than six days.

At Porcaria, in Umbria, she found a deputation of citizens of Spoleto waiting to greet her, and to accompany her to the city, which had been famous since the time of Hannibal, and which had been the seat of the mighty Lombard dukes.

The castle of Spoleto is very ancient, its earliest portions dating from the Dukes Faroald and Grimoald.

In the fourteenth century it was restored by the great Gil d'Albornoz, the contemporary of Cola di Rienzi, and it was completed shortly afterwards by Nicholas V.It is a magnificent piece of Renaissance architecture, overlooking the old city and the deep ravine which separates it from Monte Luco.

From its high windows one may look out over the valley of the Clitunno and that of the Tiber, the fertile Umbrian plain, and, on the east, to the Apennines.
August 15th Lucretia Borgia received the priors of the city, to whom she presented her papal appointment, whereupon they swore allegiance to her.
Later the commune gave a banquet in her honor.
Lucretia's stay in Spoleto was short.