She loved, and perhaps for the first time.

Alfonso wrote her from Genazzano, urgently imploring her to follow him, and his letters fell into the hands of the Pope, who compelled her to write her husband and ask him to return.

It was doubtless his daughter's complaining that induced Alexander to send her away from Rome.

August 8th he made her Regent of Spoleto.

Hitherto papal legates, usually cardinals, had governed this city and the surrounding territory; but now the Pope entrusted its administration to a young woman of nineteen, his own daughter, and thither she repaired.
He gave her a letter to the priors of Spoleto which was as follows: DEAR SONS: Greeting and the Apostolic Blessing! We have entrusted to our beloved daughter in Christ, the noble lady, Lucretia de Borgia, Duchess of Biseglia, the office of keeper of the castle, as well as the government of our cities of Spoleto and Foligno, and of the county and district about them.