Alfonso slipped away August 2, 1499.

The Pope sent some troopers after him, but they failed to catch him.

It is uncertain whether Lucretia knew of his intended flight.

A letter written in Rome by a Venetian, August 4th, merely says: "The Duke of Biseglia, Madonna Lucretia's husband, has secretly fled and gone to the Colonna in Genazzano; he deserted his wife, who has been with child for six months, and she is constantly in tears."[64] She was in the power of her father, who, highly incensed by the prince's flight, banished Alfonso's sister Donna Sancia to Naples.
Lucretia's position, owing to these circumstances, became exceedingly trying.

Her tears show that she possessed a heart.