At this court he met two men who were destined later to exercise great influence upon his career--George of Amboise, Archbishop of Rouen, to whom he had brought the cardinal's hat, and Giuliano della Rovere.

The latter, hitherto Alexander's bitterest enemy, now suffered himself, by the intermediation of the King of France, to be won over to the cause of the Borgias; he permitted himself even to become Caesar's stepping-stone to greatness.
The reconciliation was sealed by a marriage between the two families; the city prefect, Giovanni della Rovere, Giuliano's brother, betrothing his eighteen-year-old son Francesco Maria to Angela Borgia, September 2, 1500.
Angela's father, Giuffre, was a son of Giovanni, sister of Alexander VI, and of Guglielmo Lanzol.

Giovanni Borgia the younger, Cardinal Ludovico, and Rodrigo, captain of the papal guard, were her brothers.

Her sister Girolama, as above stated, was married to Fabio Orsini.

The ceremony of Angela's betrothal took place in the Vatican in the presence of the ambassador of France.
For the purpose of driving Ludovico il Moro from Milan, Louis XII had concluded an alliance with Venice, which the Pope also joined on the condition that France would help his son to acquire Romagna.
Ascanio Sforza, who was unable to prevent the loss of Milan, and who knew that his own life was in danger in Rome, fled July 13, 1499, to Genazzano and subsequently to Genoa.
His example was followed by Lucretia's youthful consort.