Sermoneta was besieged, and its inhabitants surrendered without resistance.
As early as March 9, 1499, Alexander compelled the apostolic chamber to sell his daughter the possessions of the Gaetani for eighty thousand ducats.

He stated in a document, which was signed by eighteen cardinals, that the magnitude of the expenditures which he had recently made in the interests of the Holy See compelled him to increase the Church property; and for this purpose there were Sermoneta, Bassiano, Ninfa and Norma, Tivera, Cisterna, San Felice (the Cape of Circello), and San Donato, which, owing to the rebellion of the Gaetani, might be confiscated.

This transaction was concluded in February, 1500, and Lucretia, who was already mistress of Spoleto and Nepi, thus became ruler of Sermoneta.[68] In vain did the unfortunate Giacomo Gaetani protest from his prison; July 5, 1500, he was poisoned.

His mother and sisters buried him in S.Bartolomeo, which stands on an island in the Tiber, where the Gaetani had owned a palace for a great many years.
Giulia Farnese, therefore, was unable to save her own uncle.

She was reminded that Giacomo and Nicola had stood beside her when she was married to the youthful Orsini in 1489 in the Borgia palace.