Some say she will turn nun, while others make different statements which I can not entrust to a letter."[53] We know not what prayers and what confessions Lucretia made at the altar, but this was one of the most momentous periods of her life.

While in the convent she learned of the terrible death of one of her brothers, and shuddered at the crime of the other.

For she, like her father and all the Borgias, firmly believed that Caesar was a fratricide.

She clearly discerned the marks of his inordinate ambition; she knew that he was planning to lay aside the cardinal's robe and become a secular prince; she must have known too that they were scheming in the Vatican to make Don Giuffre a cardinal in Caesar's place and to marry the latter to the former's wife, Donna Sancia, with whom, it was generally known, he was on most intimate terms.
Alexander commanded Giuffre and his young wife to leave Rome and take up their abode in his princely seat in Squillace, and he set out on August 7th for that place.

It is stated the Pope did not want his children and nepots about him any longer, and that he also wished to banish his daughter Lucretia to Valencia.[54] In the meantime, in July, Caesar had gone to Capua as papal legate, where he crowned Don Federico, the last of the Aragonese, as King of Naples.
September 4th he returned to Rome.
Alexander had appointed a commission under the direction of two cardinals for the purpose of divorcing Lucretia from Giovanni Sforza.
These judges showed that Sforza had never consummated the marriage, and that his spouse was still a virgin, which, according to her contemporary Matarazzo of Perugia, set all Italy to laughing.