He went to Genazzano and joined the Colonna, who were in the pay of France.

Charles VIII was already preparing to invade Italy.

The Pope and King Alfonso met at Vicovaro near Tivoli, July 14th.
In the meantime important changes had taken place in Lucretia's palace.
Her husband had hurriedly left Rome, as he could do as a captain of the Church, in which capacity he had to join the Neapolitan army, now being formed in Romagna under the command of the Duke Ferrante of Calabria.

By his nuptial contract he was bound to take his bride with him to Pesaro.
She was accompanied by her mother, Vannozza, Giulia Farnese, and Madonna Adriana.

Alexander himself, through fear of the plague, which had appeared, commanded them to depart.