The high birth of Dona Maria shows what brilliant connections the bastard Giovanni Borgia was able to make as a grandee of Spain, for she was the daughter of Don Enrigo Enriquez, High-Treasurer of Leon, and Dona Maria de Luna, who was closely connected with the royal house of Aragon.

Don Giovanni left Rome, August 4, 1493, to board a Spanish galley in Civitavecchia.
According to the report of the Ferrarese agent, he took with him an incredible number of trinkets, with whose manufacture the goldsmiths of Rome had busied themselves for months.
Of Alexander's sons there now remained in Rome, Caesar, who was to be made a cardinal, and Giuffre, who was destined to be a prince in Naples, for the quarrel between the Pope and King Ferdinand had been settled through the intermediation of Spain.

She caused Alexander to break with France, and to sever his connection with Ludovico il Moro.

This surprising change was immediately confirmed by the marriage of Don Giuffre, a boy of scarcely thirteen, and Donna Sancia, a natural daughter of Duke Alfonso of Calabria.

August 16, 1493, the marriage was performed by proxy in the Vatican, and the wedding took place later in Naples.
Caesar himself became cardinal, September 20, 1493, the stain of his birth having been removed by the Cardinals Pallavicini and Orsini, who had been charged with legitimating him.