She was the chief goddess of the city of Uruk.

Her temple at Uruk is first mentioned by Ur-Gur, of the second dynasty of Ur.

It is restored and enlarged by Dungi, the successor of Ur-Bau, and so thoroughly is she identified with her edifice known as E-anna (again a play upon her name), that she becomes known as the Lady of E-anna.[66] She appears to have had a temple also at Ur, and it is to this edifice that later rulers of Larsa--Kudur-Mabuk and Rim-Sin, as well as the kings of the Isin dynasty, Gamil-Ninib, Libit-Ishtar, and Ishme-Dagan--refer in their inscriptions.
The members of the Isin dynasty pride themselves upon their control over Uruk, and naturally appear as special devotees to Nana, whose chosen "consort" they declare themselves to be, wielding the sceptre, as it were, in union with her.

Already at this period, Nana is brought into connection with the moon-god, being called by Kudur-Mabuk the daughter of Sin.

The relationship in this case indicates, primarily, the supremacy exercised by Ur, and also a similarity in the traits of the two deities.