Finding no immediate access to the Indians, they gave the more constant attention to their own countrymen, both Catholic and Protestant, and were soon able to give thanks that by God's blessing on their labors almost all the Protestants of that year's arrival had been converted, besides many others.

In 1640 the first-fruits of their mission work among the savages were gathered in; the chief of an Indian village on the Potomac nearly opposite Mount Vernon, and his wife and child, were baptized with solemn pomp, in which the governor and secretary of the colony took part.
The first start of the Maryland colony was of a sort to give promise of feuds and border strifes with the neighbor colony of Virginia, and the promise was abundantly fulfilled.

The conflict over boundary questions came to bloody collisions by land and sea.

It is needless to say that religious differences were at once drawn into the dispute.

The vigorous proselytism of the Jesuit fathers, the only Christian ministers in the colony, under the patronage of the lord proprietor was of course reported to London by the Virginians; and in December, 1641, the House of Commons, then on the brink of open rupture with the king, presented a remonstrance to Charles at Hampton Court, complaining that he had permitted "another state, molded within this state, independent in government, contrary in interest and affection, secretly corrupting the ignorant or negligent professors of religion, and clearly uniting themselves against such." Lord Baltimore, perceiving that his property rights were coming into jeopardy, wrote to the too zealous priests, warning them that they were under English law and were not to expect from him "any more or other privileges, exemptions, or immunities for their lands, persons, or goods than is allowed by his Majesty or officers to like persons in England." He annulled the grants of land made to the missionaries by certain Indian chiefs, which they affected to hold as the property of their order, and confirmed for his colony the law of mortmain.