He was the first surgeon to perform the suprapubic lithotomy operation--the removal of stone through the abdomen instead of through the perineum.

His works, while written in an illiterate style, give the clearest descriptions of any of the early modern writers.
As the fame of Franco rests upon his operation for prolonging human life, so the fame of his Italian contemporary, Gaspar Tagliacozzi (1545-1599), rests upon his operation for increasing human comfort and happiness by restoring amputated noses.

At the time in which he lived amputation of the nose was very common, partly from disease, but also because a certain pope had fixed the amputation of that member as the penalty for larceny.

Tagliacozzi probably borrowed his operation from the East; but he was the first Western surgeon to perform it and describe it.

So great was the fame of his operations that patients flocked to him from all over Europe, and each "went away with as many noses as he liked." Naturally, the man who directed his efforts to restoring structures that bad been removed by order of the Church was regarded in the light of a heretic by many theologians; and though he succeeded in cheating the stake or dungeon, and died a natural death, his body was finally cast out of the church in which it had been buried.
In the sixteenth century Germany produced a surgeon, Fabricius Hildanes (1560-1639), whose work compares favorably with that of Pare, and whose name would undoubtedly have been much better known had not the circumstances of the time in which he lived tended to obscure his merits.