In 1811, with her husband, she first saw the Forks of Red River and wintered in 1811-12 at Pembina, the winter which the first band of Colonists spent at York Factory.

Lajimoniere became a fast adherent of Lord Selkirk, and made a famous and most dangerous winter journey through the wilds alone, carrying letters from Red River to Montreal, delivered them personally to Lord Selkirk in 1815.
The Lajimonieres received with great delight in 1818 the first Roman Catholic missionaries who reached Red River.

These were sent through Lord Selkirk's influence, and the large gift of land known as the Seigniory lying east of St.Boniface was the reward given to the early pioneer missionaries--Provencher and Dumoulin, men of great stature and manly bearing.

In the year of their arrival James Sutherland, the Presbyterian chaplain of the Selkirk Colonists, was taken by the Nor'-Westers to Upper Canada, whither his son, Haman Sutherland, had gone in 1815 with Duncan Cameron.

The Earl of Selkirk had promised to send to his Scottish Colonists a minister of their own faith.