Both commanders were sick, and, nearing the Line, on the 30th of July, Loaysa died.

Four days after, Sebastian del Cano, who had escaped and weathered so many storms and dangers, expired also, leaving the command of the expedition to Alonzo de Salazar.
Salazar steered for the Ladrones.

On the 4th of September he arrived at that group, where he met Gonzalo de Vigo, one of the seamen of the _Trinidad_.
From the Ladrones the expedition sailed for the Philippines, and on the way Alonzo de Salazar, the third commander, died.
Martin de Iniquez was now appointed to the command, and it was November before they came to anchor at Zamofo, a port in an island belonging to the King of Tidor, who had become their ally during their previous voyage.
Disputes immediately arose between the Spaniards and the Portuguese commander settled at Ternate.

A war ensued, which lasted for several years, with various degrees of success and activity, the people of Tidor supporting the Spaniards and those of Ternate the Portuguese settlers.
Galvano, the Portuguese historian of the Moluccas, and a resident there for many years, informs us that only one vessel of Loaysa's fleet reached the Spice Islands.

The fourth commander, Martin de Iniquez, died some time after, poisoned, it is said, and the command of the remnant of the expedition was entrusted to Hernando de la Torre.