174.] [Footnote 220: It maybe worth mentioning that Virginio Orsini, Bracciano's son and heir, married Donna Flavia, grand niece of Sixtus V., and consequently related to the man his father murdered in order to possess Vittoria Accoramboni.

See Mutinelli, _Storia Arcana_, vol.ii.
p.

72.] Both of these murders took place in 1576.

Isabella's death, as I have elsewhere related, opened the way for the Duke of Bracciano's marriage with Vittoria Accoramboni, which had been prepared by the assassination of her first husband, and which led to her own murder at Padua.[221] Another of Cosimo's daughters, Lucrezia de'Medici, became Duchess of Ferrara, fell under a suspicion of infidelity, and was possibly removed by poison in 1561.[222] The last of his sons whom I have to mention, Don Giovanni, married a dissolute woman of low birth called Livia, and disgraced the name of Medici by the unprincely follies of his life.
Eleonora de'Medici, third of his daughters, introduces a comic element into these funereal records.

She was affianced to Vincenzo Gonzaga, heir of the Duchy of Mantua.