If the administration causes pain (due in part to the large quantity used and in part to the local effect of glycerin), a fraction of a grain of cocaine may be added to the solution when measured out for use.
It may at once be said, emphatically, that in some cases remarkable results have followed the use of this material, while in others no good has been done; but the same may be said of most plans of treatment in this disorder.

As to possible danger from it, no harm has been done to any patient known to me, except that abcesses have occurred sometimes, though very rarely, for in many hundreds of injections it has been my good fortune to see abscesses form only three or four times, two of these instances, by curious ill luck, being in physicians.

Patients describe a stimulating effect not unlike that of strong coffee, following a few hours after use and lasting for a day.

The sexual appetite, if present, is increased; if absent, it is often renewed, sometimes in elderly men to an inconvenient extent.

In one tabetic subject who had lost desire and ability for more than three years both returned in sufficient force to allow him to beget a child.