The effect is at its height twelve to twenty-four hours after the administration in most patients, hence the reason for using it only once in two days.

The skin is prepared, the needles and syringe disinfected, and the tiny puncture sealed afterwards with as minute care as would be given to a surgical operation.

By these precautions the danger of abscess, always considerable if hypodermics are carelessly given, is minimized.

As the dose is large, a site must be selected for the injection where the tissue is loose, otherwise the pain will interfere with the desired frequency of use.

The buttocks serve best, or the outer masses of the pectoral muscles, or the abdominal muscles.