At the close of the second she had to relinquish all her gains, and to draw back even behind the line which she occupied when hostilities first broke out.

Nisibis, the great stronghold of Eastern Mesopotamia, had been in her possession ever since the time of Verus.
Repeatedly attacked by Parthia and Persia, it had never fallen; but once, after which it had been soon recovered; and now for many years it had come to be regarded as the bulwark of the Roman power in the East, and as carrying with it the dominion of Western Asia.102 A fatal blow was dealt to Roman prestige when a city held for near two hundred years, and one honored with the name of "colony," was wrested from the empire and occupied by the most powerful of its adversaries.

Not only Amida and Carrhae, but Antioch itself, trembled at a loss which was felt to lay open the whole eastern frontier to attack, and which seemed ominous of further retrogression.

Although the fear generally felt proved to be groundless, and the Roman possessions in the East were not, for 200 years, further curtailed by the Persians, yet Roman influence in Western Asia from this time steadily declined, and Persia came to be regarded as the first power in these regions.

Much credit is due to Sapor II.