By her he had issue two sons and at least three daughters.

The sons were Cambyses and Smerdis; the daughters Atossa, Artystone, and one whose name is unknown to us.
Cassandane died before her husband, and was deeply mourned by him.
Shortly before his own death he took the precaution formally to settle the succession.

Leaving the general inheritance of his vast dominions to his elder son, Cambyses, he declared it to be his will that the younger should be entrusted with the actual government of several large and important provinces.

He thought by this plan to secure the well-being of both the youths, never suspecting that he was in reality consigning both to untimely ends, and even preparing the way for an extraordinary revolution.
The ill effect of the unfortunate arrangement thus made appeared almost immediately.

Cambyses was scarcely settled upon the throne before he grew jealous of his brother, and ordered him to be privately put to death.