The highest estimate places it at 450 killed, the lowest at 182.

Besides these, 504 were wounded.

Thus Alexander had less than 1000 men placed hors de combat.

He himself received a slight wound in the thigh from a sword, which, used a little more resolutely, might have changed the fortunes of the world.
The defeat of the Persians at Issus seems to have been due simply to the fact that, practically, the two adversaries engaged with almost equal numbers, and that the troops of Alexander were of vastly superior quality to those of Darhis.

The Asiatic infantry--notwithstanding their proud title of "braves"-- proved to be worthless; the Greek mercenaries were personally courageous, but their inferior arms and training rendered them incapable of coping with the Macedonian phalanx.