Terituchmes was the son of Idernes, a Persian noble of high rank, probably a descendant of the conspirator Hydarnes.

On the death of his father, he succeeded to his satrapy, as to a hereditary fief, and being high in favor with Darius Nothus, he received in marriage that monarch's daughter, Amestris.

Having, however, after his marriage become enamored of his own half-sister, Roxana, and having persuaded her to an incestuous commerce, he grew to detest his wife, and as he could not rid himself of her without making an enemy of the king, he entered into a conspiracy with 300 others, and planned to raise a rebellion.

The bond of a common crime, cruel and revolting in its character, was to secure the fidelity of the rebels one to another.
Amestris was to be placed in a sack, and each conspirator in turn was to plunge his sword into her body.

It is not clear whether this intended murder was executed or no.