This John may possibly have been Lucrezia's child.

The Dukedom of Sermoneta, wrenched for a moment from the hands of the Gaetani family, who still own it, was conferred upon Lucrezia's son, Roderigo.

Lucrezia, the only daughter of Alexander by Vannozza, took three husbands in succession, after having been formally betrothed to two Spanish nobles, Don Cherubino Juan de Centelles, and Don Gasparo da Procida, son of the Count of Aversa.

These contracts, made before her father became Pope, were annulled as not magnificent enough for the Pontiff's daughter.

In 1492 she was married to Giovanni Sforza, Lord of Pesaro.