The increased production of cotton led directly to increased demand for slave labor and slave soil.

The increased demand for slave labor the Constitutional provision relating to the African slave trade operated in part to satisfy.

The increased demand for slave soil was likewise satisfied by the cession to the United States by Georgia and North Carolina of the Southwest Territory, with provisos practically securing it to slavery.

Out of this new national territory were subsequently carved the slave States of Tennessee, Mississippi, and Alabama.
Slave soil unlike free soil, is incapable of sustaining a dense population.

Slave labor calls for large spaces within which to multiply and prosper.