In a battle that ensued among the mountain-defiles at Issus, the Persians were again overthrown.

So great was the slaughter that Alexander, and Ptolemy, one of his generals, crossed over a ravine choked with dead bodies.

It was estimated that the Persian loss was not less than ninety thousand foot and ten thousand horse.

The royal pavilion fell into the conqueror's hands, and with it the wife and several of the children of Darius.

Syria was thus added to the Greek conquests.