He and his wife there took a fever which after baffling the physicians was cured by his own prescription.

He then moved to Cotton Gin Port to take charge of a store, but was invalided for three years by a sunstroke.

Gradually recovering, he lived in the woods on light diet until the thought occurred to him of carrying a company of Choctaw ball players on a tour of the United States.
The tour was made, but the receipts barely covered expenses.

Then in 1830, Lincecum set himself up as a physician at Columbus.

No sooner had he built up a practice, however, than he became dissatisfied with allopathy and went to study herb remedies among the Indians; and thereafter he practiced botanic medicine.