Pare in 1549 gives several instances of 5 children at a birth, and Pliny reports that in the peninsula of Greece there was a woman who gave birth to quintuplets on four different occasions.

Petritus, a Greek physician, speaks of the birth of quintuplets at the seventh month.

Two males and one female were born dead, being attached to the same placenta; the others were united to a common placenta and lived three days.

Chambon mentions an instance of 5 at a birth.

Not far from Berne, Switzerland, the wife of John Gelinger, a preacher in the Lordship of Berne, brought forth twins, and within a year after she brought forth quintuplets, 3 sons and 2 daughters.