His chief work is at Cortona, at Rome (in the Sixtine Chapel), and at Orvieto.

His fame was sufficient in Florence in 1491 for him to be made one of the judges of the designs for the facade of the Duomo.

Luca lived to a great age, not dying till 1524, and was much beloved.

He was magnificent in his habits and loved fine clothes, was very kindly and helpful in disposition, and the influence of his naturalness and sincerity upon art was great.

One very pretty sad story is told of him, to the effect that when his son, whom he had dearly loved, was killed at Cortona, he caused the body to be stripped, and painted it with the utmost exactitude, that through his own handiwork he might be able to contemplate that treasure of which fate had robbed him.