He was a kindly, melancholy man with a deep sense of human injustice; and in 1535, when, after Clement VII's very welcome demise, the Florentine exiles who either had been banished from Florence by Alessandro or had left of their own volition rather than live in the city under such a contemptible ruler, sent an embassy to the Emperor Charles V to help them against this new tyrant, Ippolito headed it; but Alessandro prudently arranged for his assassination en route.
It is unlikely, however, that the Emperor would have done anything, for in the following year he allowed his daughter Margaret to become Alessandro's wife.

That was in 1536.

In January, 1537, Lorenzino de' Medici, a cousin, one of the younger branch of the family, assuming the mantle of Brutus, or liberator, stabbed Alessandro to death while he was keeping an assignation in the house that then adjoined this palace.

Thus died, at the age of twenty-six, one of the most worthless of men, and, although illegitimate, the last of the direct line of Cosimo de' Medici, the Father of his Country, to govern Florence.
The next ruler came from the younger branch, to which we now turn.

Old Giovanni di Bicci had two sons, Cosimo and Lorenzo.