Alessio was an independent man who painted from taste and not necessity.
Ghirlandaio's chief influences, however, were Masaccio, at the Carmine, Fra Lippo Lippi, and Verrocchio, who is thought also to have been Baldovinetti's pupil and whose Baptism of Christ, in the Accademia, painted when Ghirlandaio was seventeen, must have given Ghirlandaio the lines for his own treatment of the incident in this church.

One has also only to compare Verrocchio's sculptured Madonnas in the Bargello with many of Ghirlandaio's to see the influence again; both were attracted by a similar type of sweet, easy-natured girl.
When he was twenty-six Ghirlandaio went to Rome to paint the Sixtine library, and then to San Gimignano, where he was assisted by Mainardi, who was to remain his most valuable ally in executing the large commissions which were to come to his workshop.

His earliest Florentine frescoes are those which we shall see at Ognissanti; the Madonna della Misericordia and the Deposition painted for the Vespucci family and only recently discovered, together with the S.Jerome, in the church, and the Last Supper, in the refectory.

By this time Ghirlandaio and Botticelli were in some sort of rivalry, although, so far as I know, friendly enough, and both went to Rome in 1481, together with Perugino, Piero di Cosimo, Cosimo Rosselli, Luca Signorelli and others, at the command of Pope Sixtus IV to decorate the Sixtine chapel, the excommunication of all Florentines which the Pope had decreed after the failure of the Pazzi Conspiracy to destroy the Medici (as we saw in chapter II) having been removed in order to get these excellent workmen to the Holy City.

Painting very rapidly the little band had finished their work in six months, and Ghirlandaio was at home again with such an ambition and industry in him that he once expressed the wish that every inch of the walls of Florence might be covered by his brush--and in those days Florence had walls all round it, with twenty-odd towers in addition to the gates.