So that whatever is considered by us to conduce or operate to the producing any particular simple idea, or collection of simple ideas, whether substance or mode, which did not before exist, hath thereby in our minds the relation of a cause, and so is denominated by us.
2.

Creation Generation, making Alteration.
Having thus, from what our senses are able to discover in the operations of bodies on one another, got the notion of cause and effect, viz.
that a cause is that which makes any other thing, either simple idea, substance, or mode, begin to be; and an effect is that which had its beginning from some other thing; the mind finds no great difficulty to distinguish the several originals of things into two sorts:-- First, When the thing is wholly made new, so that no part thereof did ever exist before; as when a new particle of matter doth begin to exist, IN RERUM NATURA, which had before no being, and this we call CREATION.
Secondly, When a thing is made up of particles, which did all of them before exist; but that very thing, so constituted of pre-existing particles, which, considered all together, make up such a collection of simple ideas, had not any existence before, as this man, this egg, rose, or cherry, &c.

And this, when referred to a substance, produced in the ordinary course of nature by internal principle, but set on work by, and received from, some external agent, or cause, and working by insensible ways which we perceive not, we call GENERATION.

When the cause is extrinsical, and the effect produced by a sensible separation, or juxta-position of discernible parts, we call it MAKING; and such are all artificial things.

When any simple idea is produced, which was not in that subject before, we call it ALTERATION.