Mead supervised the inoculations, and all recovered.

In the following year two members of the royal family underwent the operation successfully.

Thereafter, it became, in most circles, fashionable.
"I suppose," Lady Mary wrote with pardonable pride to Lady Mar in the spring of 1722, "that the same faithful historians give you regular accounts of the growth and spreading of the inoculation of the small-pox, which is become almost a general practice, attended with great success." Elated as she was at the success that had resulted from her persistent efforts, she was correspondingly distressed when a young relative died of the disease.

"I am sorry to inform you of the death, of our nephew, my sister Gower's son, of the small-pox," she said in a letter to Lady Mar in July, 1723.

"I think she has a great deal of regret it, in consideration of the offer I made her, two years together, of taking the child home to my house, where I would have inoculated him with the same care and safety I did my own.