Thirdly, Jeanne laboured under physical difficulties which rendered her incapable of maternity.
Of such a nature was the appeal he made to Alexander, and Alexander responded by appointing a commission presided over by the Cardinal of Luxembourg, and composed of that same cardinal and the Bishops of Albi and Ceuta, assisted by five other bishops as assessors, to investigate the king's grievance.

There appears to be no good reason for assuming that the inquiry was not conducted fairly and honourably or that the finding of the bishops and ultimate annulment of the marriage was not in accordance with their consciences.

We are encouraged to assume that all this was indeed so, when we consider that Jeanne de Valois submitted without protest to the divorce, and that neither then nor subsequently at any time did she prefer any complaint, accepting the judgement, it is presumable, as a just and fitting measure.
She applied to the Pope for permission to found a religious order, whose special aim should be the adoration and the emulation of the perfections of the Blessed Virgin, a permission which Alexander very readily accorded her.

He was, himself, imbued with a very special devotion for the Mother of the Saviour.

We see the spur of this special devotion of his in the votive offering of a silver effigy to her famous altar of the Santissima Nunziata in Florence, which he had promised in the event of Rome being freed from Charles VIII.