Della Rovere, conceiving that in France he had a stouter ally than in Naples, and seeing that he had once more incurred the papal anger by his open enmity, fled back to Ostia; and, not feeling safe there, for the pontifical forces were advancing upon his fortress, took ship to Genoa, and thence to France, to plot the Pope's ruin with the exasperated Charles; and, the charge of simony being the only weapon with which they could attack Alexander's seat upon the papal throne, the charge of simony was once more brandished.
His Holiness took the matter with a becoming and stately calm.

He sent his nephew, Giovanni Borgia, to Naples to crown Alfonso, and with him went Giuffredo Borgia to carry out the marriage contract with Alfonso's daughter, and thus strengthen the alliance between Rome and Naples.
By the autumn Charles had crossed the Alps with the most formidable army that had ever been sent out of France, full ninety thousand strong.

And so badly was the war conducted by the Neapolitan generals who were sent to hold him in check that the appearance of the French under the very walls of Rome was almost such as to take the Pope by surprise.

Charles's advance from the north had been so swift and unhindered that Alexander contemptuously said the French soldiers had come into Italy with wooden spurs and chalk in their hands to mark their lodgings.
Charles had been well received by the intriguing Lodovico Sforza, with whom he visited the Castle of Pavia and the unfortunate Gian Galeazzo, who from long confinement, chagrin, and other causes was now reduced to the sorriest condition.

Indeed, on October 22, some days after that visit, the wretched prince expired.